I. Multiscale Methods -a Heat Shock Response Model

Supplementary material for “ A multiscale approximation in a heat shock response model of E . coli ”

Expression of Regulated Oncogen-Alpha by Primary Hepatocytes Following Isolation and Heat Shock Stimulation

High levels of regulated oncogen-alpha (GRO-a) expression have been observed in the liver. GRO-a stimulates proliferation of epithelial cells and induction of rolling and extravascular migration of neutrophils and mononuclear cells. Given the above observations, this chemokine was chosen to be analyzed in freshly isolated and cultured hepatocytes. In this study, hepatocytes (2×106 cell/ml) were...

Dynamics of Macro–Nano Mechanical Systems; Fixed Interfacial Multiscale Method

The continuum based approaches don’t provide the correct physics in atomic scales. On the other hand, the molecular based approaches are limited by the length and simulated process time. As an attractive alternative, this paper proposes the Fixed Interfacial Multiscale Method (FIMM) for computationally and mathematically efficient modeling of solid structures. The approach is applicable to mult...

Multiscale stochastic simulation algorithm with stochastic partial equilibrium assumption for chemically reacting systems

In this paper, we introduce a multiscale stochastic simulation algorithm (MSSA) which makes use of Gillespie s stochastic simulation algorithm (SSA) together with a new stochastic formulation of the partial equilibrium assumption (PEA). This method is much more efficient than SSA alone. It works even with a very small population of fast species. Implementation details are discussed, and an appl...

Heat Shock Proteins Enriched-Promastigotes of Leishmania major Inducing Th2 Immune Response in BALB/c Mice

Background: Heat shock proteins (HSP) are highly conserved molecules with many immunological functions. They are highly immunogenic with important role in cancer immunotherapy and in vaccine development against infectious diseases. As adjuvant, HSP can augment the immunogenicity of weak antigens and can stimulate antigen presenting cells. Although vaccines have been successful for many infec...